… This approach uses existing data to determine threshold … number of animals used in regulatory
ecotoxicity testing. These … safety regulations; a move toward extrapolating the toxicity of …

… toxicity to be generated prior to PMN submission. In the absence of these data, the US EPA
has used … property prediction models and data sources used in regulatory and/or academic …

… the analysis of new toxicological and exposure data, resulting in human exposure guidelines
… into regulatory practice. Future perspectives on the continued evolution of toxicity testing to …

… databases, and expert systems frequently used for ecotoxicity … relationship (QSAR /QSTR)
approach represents a convincing … the data gaps, government and nongovernment regulatory …

… in conducting ecotoxicity tests. Ultimately, we gathered data from 14 OECD and 2 US EPA
… trout are used annually in relation to two key Canadian regulations governing effluent …

… toxicity data is a prerequisite for determining other toxicity … In a recent perspective,
Cronin assessed the current status … toxicity predictions as well as their regulatory uses [17]. …

… values are used by regulators as toxicity indices to … approach has been adopted by the
OECD in a guidance document “Current approaches in the statistical analysis of ecotoxicity data…

… CA models are the most frequently applied, because they generally provide reliable
estimates of combined effects, they can more easily be used with existing toxicity data and are …

… With the approach of the twentieth anniversary of the database, … However, for non-regulatory
applications, it is not unusual for … US ECOTOX database is used as a source for ecotoxicity …

… traditionally relied upon toxicity data from animal bioassays and … The shift in approach goes
hand-in-hand with rapid data … its use across the broader scientific and regulatory communities…